EC 2.7.1.95 - Kanamycin kinase

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IntEnz Enzyme Nomenclature
EC 2.7.1.95

Names

Accepted name:
kanamycin kinase
Other names:
kanamycin kinase (phosphorylating)
neomycin phosphotransferase
neomycin-kanamycin phosphotransferase
Systematic name:
ATP:kanamycin 3'-O-phosphotransferase

Reaction

Comments:

Also acts on the antibiotics neomycin, paromomycin, neamine, paromamine, vistamycin and gentamicin A. An enzyme from Pseudomonas aeruginosa also acts on butirosin.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0008910
CAS Registry Number: 62213-36-9
UniProtKB/Swiss-Prot: (12) [show] [UniProt]

References

  1. Doi, O., Ogura, M., Tanaka, N. and Umezawa, H.
    Inactivation of kanamycin, neomycin, and streptomycin by enzymes obtained in cells of Pseudomonas aeruginosa.
    Appl. Microbiol. 16: 1276-1281 (1968). [PMID: 4970990]
  2. Dolin, M.I.
    The Streptococcus faecalis oxidases for reduced diphosphopyridine nucleotide. III. Isolation and properties of a flavin peroxidase for reduced diphosphopyridine nucleotide.
    J. Biol. Chem. 225: 557-573 (1957).

[EC 2.7.1.95 created 1976]