EC 2.7.1.68 - 1-phosphatidylinositol-4-phosphate 5-kinase

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ENZYME: 2.7.1.68


ID   2.7.1.68
DE   1-phosphatidylinositol-4-phosphate 5-kinase.
AN   Diphosphoinositide kinase.
AN   Phosphatidylinositol 4-phosphate kinase.
AN   Phosphatidylinositol-4-phosphate 5-kinase.
AN   PIP kinase.
AN   PtdIns(4)P-5-kinase.
AN   Type I PIP kinase.
CA   ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate = ADP + 1-phosphatidyl-
CA   1D-myo-inositol 4,5-bisphosphate.
CC   -!- This enzyme can also phosphorylate PtdIns3P in the 4-position,
CC       and PtdIns, PtdIns3P and PtdIns(3,4)P(2) in the 5-position in vitro,
CC       but to a lesser extent.
CC   -!- The last of these reactions occurs in vivo and is physiologically
CC       relevant.
DR   O13853    , ITS3_SCHPO ;  P38994    , MSS4_YEAST ;  Q99755    , PI51A_HUMAN;
DR   P70182    , PI51A_MOUSE;  D3ZSI8    , PI51A_RAT  ;  Q5ZJ58    , PI51B_CHICK;
DR   O14986    , PI51B_HUMAN;  P70181    , PI51B_MOUSE;  Q5CZZ9    , PI51B_RAT  ;
DR   O60331    , PI51C_HUMAN;  O70161    , PI51C_MOUSE;  Q5I6B8    , PI51C_RAT  ;
DR   Q56YP2    , PI5K1_ARATH;  Q6EX42    , PI5K1_ORYSJ;  Q8L796    , PI5K2_ARATH;
DR   O48709    , PI5K3_ARATH;  Q9M1K2    , PI5K4_ARATH;  Q9SLG9    , PI5K5_ARATH;
DR   Q9SFB8    , PI5K6_ARATH;  Q9SUI2    , PI5K7_ARATH;  Q8RY89    , PI5K8_ARATH;
DR   Q8L850    , PI5K9_ARATH;  Q9LMN1    , PI5KA_ARATH;  Q9M149    , PI5KB_ARATH;
DR   Q17QS4    , PI5L1_BOVIN;  Q5T9C9    , PI5L1_HUMAN;  Q6U7H8    , PI5L1_MOUSE;
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