EC 2.5.1.38 - Isonocardicin synthase

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IntEnz Enzyme Nomenclature
EC 2.5.1.38

Names

Accepted name:
isonocardicin synthase
Other names:
nocardicin aminocarboxypropyltransferase
S-adenosyl-L-methionine:nocardicin-E 3-amino-3-carboxypropyltransferase
Systematic name:
S-adenosyl-L-methionine:nocardicin-G 3-amino-3-carboxypropyltransferase

Reactions

Comments:

The enzyme, characterized from the bacterium Nocardia uniformis, is involved in the biosynthesis of the β-lactam antibiotic nocardicin A. The enzyme can act on nocardicin E, F, and G, producing isonocardicin A, B, and C, respectively. However, the in vivo substrate is believed to be nocardicin G [3].

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0050007
CAS Registry Number: 118246-74-5

References

  1. Wilson, B.A., Bantia, S., Salituro, G.M., Reeve, A.M. and Townsend, C.A.
    Cell-free biosynthesis of nocardicin A from nocardicin E and S-adenosylmethionine.
    J. Am. Chem. Soc. 110: 8238-8239 (1988).
  2. Reeve, A. M., Breazeale, S. D., Townsend, C. A.
    Purification, characterization, and cloning of an S-adenosylmethionine-dependent 3-amino-3-carboxypropyltransferase in nocardicin biosynthesis.
    J. Biol. Chem. 273: 30695-30703 (1998). [PMID: 9804844]
  3. Kelly, W. L., Townsend, C. A.
    Mutational analysis of nocK and nocL in the nocardicin a producer Nocardia uniformis.
    J. Bacteriol. 187: 739-746 (2005). [PMID: 15629944]

[EC 2.5.1.38 created 1992, modified 2016]