EC - Purine-nucleoside phosphorylase

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IntEnz Enzyme Nomenclature


Accepted name:
purine-nucleoside phosphorylase
Other names:
inosine phosphorylase
inosine-guanosine phosphorylase
nucleotide phosphatase
purine deoxynucleoside phosphorylase
purine deoxyribonucleoside phosphorylase
purine nucleoside phosphorylase
purine ribonucleoside phosphorylase
Systematic name:
purine-nucleoside:phosphate ribosyltransferase



Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC, nucleoside ribosyltransferase.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , NIST 74 , UniPathway
Protein domains and families: PROSITE:PDOC00946 , PROSITE:PDOC00954
Structural data: CSA , EC2PDB
Gene Ontology: GO:0004731
CAS Registry Number: 9030-21-1
UniProtKB/Swiss-Prot: (228) [show] [UniProt]


  1. Agarwal, R.P. and Parks, R.E.
    Purine nucleoside phosphorylase from human erythrocytes. IV. Crystallization and some properties.
    J. Biol. Chem. 244: 644-647 (1969). [PMID: 5768862]
  2. Friedkin, M. and Kalckar, H.
    Nucleoside phosphorylases.
    In: Boyer, P.D., Lardy, H. and Myrbäck, K. (Eds.) The Enzymes, 2nd ed. vol. 5, Academic Press, New York, 1961, 237-255
  3. Heppel, L.A. and Hilmoe, R.J.
    Phosphorolysis and hydrolysis of purine ribosides from yeast.
    J. Biol. Chem. 198: 683-694 (1952). [PMID: 12999785]
  4. Kalckar, H.M.
    The enzymatic synthesis of purine ribosides.
    J. Biol. Chem. 167: 477-486 (1947).
  5. Saunders, P.P., Wilson, B.A. and Saunders, G.F.
    Purification and comparative properties of a pyrimidine nucleoside phosphorylase from Bacillus stearothermophilus.
    J. Biol. Chem. 244: 3691-3697 (1969). [PMID: 4978445]
  6. Tsuboi, K.K. and Hudson, P.B.
    Enzymes of the human erythrocyte. I. Purine nucleoside phosphorylase; isolation procedure.
    J. Biol. Chem. 224: 879-887 (1957). [PMID: 13405917]

[EC created 1961]