EC 2.4.1.66 - Procollagen glucosyltransferase

  IntEnz view ENZYME view

IntEnz Enzyme Nomenclature
EC 2.4.1.66

Names

Accepted name:
procollagen glucosyltransferase
Other names:
UDP-glucose-collagenglucosyltransferase
UDPglucose:5-(D-galactosyloxy)-L-lysine-procollagen D-glucosyltransferase
collagen glucosyltransferase
collagen hydroxylysyl glucosyltransferase
galactosylhydroxylysine glucosyltransferase
galactosylhydroxylysyl glucosyltransferase
uridine diphosphoglucose-collagen glucosyltransferase
galactosylhydroxylysine-glucosyltransferase
UDP-glucose:5-(D-galactosyloxy)-L-lysine-procollagen D-glucosyltransferase
UDP-glucose:(2S,5R)-5-O-(β-D-galactosyl)-5-hydroxy-lysine-[procollagen] D-glucosyltransferase
Systematic name:
UDP-α-D-glucose + [procollagen]-(2S,5R)-5-O-(β-D-galactosyl)-5-hydroxy-L-lysine 2-α-D-glucosyltransferase (configuration-retaining)

Reaction

Comments:

Involved in the synthesis of carbohydrate units in complement (cf. EC 2.4.1.50 procollagen galactosyltransferase).

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0033823
CAS Registry Number: 9028-08-4
UniProtKB/Swiss-Prot:

References

  1. Bosmann, H.B. and Eylar, E.H.
    Attachment of carbohydrate to collagen. Isolation, purification and properties of the glucosyl transferase.
    Biochem. Biophys. Res. Commun. 30: 89-94 (1968). [PMID: 5637038]
  2. Bosmann, H.B. and Eylar, E.H.
    Collagen-glucosyl transferase in fibriblasts transformed by oncogenic viruses.
    Nature 218: 582-583 (1968). [PMID: 4968368]
  3. Butler, W.T. and Cunningham, L.W.
    Evidence for the linkage of a disaccharide to hydroxylysine in tropocollagen.
    J. Biol. Chem. 241: 3882-3888 (1966). [PMID: 4288358]
  4. Kivirikko, K.I. and Myllyla, R.
    In: Hall, D.A. and Jackson, D.S. (Eds.) International Review of Connective Tissue Research vol. 8, Academic Press, New York, 1979, 23
  5. Sricholpech, M., Perdivara, I., Nagaoka, H., Yokoyama, M., Tomer, K. B., Yamauchi, M.
    Lysyl hydroxylase 3 glucosylates galactosylhydroxylysine residues in type I collagen in osteoblast culture.
    J. Biol. Chem. 286: 8846-8856 (2011). [PMID: 21220425]

[EC 2.4.1.66 created 1972]