EC 2.4.1.53 - Poly(ribitol-phosphate) β-glucosyltransferase

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IntEnz Enzyme Nomenclature
EC 2.4.1.53

Names

Accepted name:
poly(ribitol-phosphate) β-glucosyltransferase
Other names:
UDP glucose-poly(ribitol-phosphate) β-glucosyltransferase
UDP-D-glucose polyribitol phosphate glucosyl transferase
UDP-D-glucose:polyribitol phosphate glucosyl transferase
UDP-glucose:poly(ribitol-phosphate) β-D-glucosyltransferase
uridine diphosphoglucose-poly(ribitol-phosphate) β-glucosyltransferase
TarQ
Systematic name:
UDP-α-D-glucose:4-O-[(1-D-ribitylphospho)n-(1-D-ribitylphospho)-(2R)-1-glycerophospho]-N-acetyl-β-D-mannosaminyl-(1→4)-N-acetyl-α-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol β-D-glucosyltransferase (configuration-inverting)

Reaction

Comments:

Involved in the biosynthesis of poly ribitol phosphate teichoic acids in the cell wall of the bacterium Bacillus subtilis W23. This enzyme adds a β-D-glucose to the hydroxyl group at the 2 position of the ribitol phosphate units.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0047266
CAS Registry Number: 37277-61-5
UniProtKB/Swiss-Prot:

References

  1. Chin, T., Burger, M.M. and Glaser, L.
    Synthesis of teichoic acids. VI. The formation of multiple wall polymers in Bacillus subtilis W-23.
    Arch. Biochem. Biophys. 116: 358-367 (1966). [PMID: 4960203]
  2. Brown, S., Xia, G., Luhachack, L. G., Campbell, J., Meredith, T. C., Chen, C., Winstel, V., Gekeler, C., Irazoqui, J. E., Peschel, A., Walker, S.
    Methicillin resistance in Staphylococcus aureus requires glycosylated wall teichoic acids.
    Proc. Natl. Acad. Sci. U.S.A. 109: 18909-18914 (2012). [PMID: 23027967]

[EC 2.4.1.53 created 1972, modified 2018]