EC 2.4.1.50 - Procollagen galactosyltransferase

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IntEnz Enzyme Nomenclature
EC 2.4.1.50

Names

Accepted name:
procollagen galactosyltransferase
Other names:
UDP galactose-collagen galactosyltransferase
UDPgalactose:5-hydroxylysine-collagen galactosyltransferase
UDPgalactose:procollagen-5-hydroxy-L-lysine D-galactosyltransferase
collagen galactosyltransferase
collagen hydroxylysyl galactosyltransferase
hydroxylysine galactosyltransferase
uridine diphosphogalactose-collagen galactosyltransferase
UDP-galactose:procollagen-5-hydroxy-L-lysine D-galactosyltransferase
UDP-α-D-galactose:procollagen-5-hydroxy-L-lysine D-galactosyltransferase
Systematic name:
UDP-α-D-galactose:[procollagen]-(2S,5R)-5-hydroxy-L-lysine 5-β-D-galactosyltransferase (configuration-inverting)

Reaction

Comments:

Involved in the synthesis of carbohydrate units in complement (cf EC 2.4.1.66, procollagen glucosyltransferase).

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0050211
CAS Registry Number: 9028-07-3
UniProtKB/Swiss-Prot: (13) [show] [UniProt]

References

  1. Bosmann, H.B. and Eylar, E.H.
    Glycoprotein biosynthesis: the biosynthesis of the hydroxylysine-galactose linkage in collagen.
    Biochem. Biophys. Res. Commun. 33 : 340-346 (1968). [PMID: 5722225]
  2. Kivirikko, K.I. and Myllyla, R.
    In: Hall, D.A. and Jackson, D.S. (Eds.) International Review of Connective Tissue Research vol. 8 , Academic Press , New York , 1979 , 23
  3. Schegg, B., Hulsmeier, A. J., Rutschmann, C., Maag, C., Hennet, T.
    Core glycosylation of collagen is initiated by two beta(1-O)galactosyltransferases.
    Mol. Cell. Biol. 29 : 943-952 (2009). [PMID: 19075007]

[EC 2.4.1.50 created 1972, modified 1983]