EC 2.3.1.149 - Platelet-activating factor acetyltransferase

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IntEnz Enzyme Nomenclature
EC 2.3.1.149

Names

Accepted name:
platelet-activating factor acetyltransferase
Other name:
PAF acetyltransferase
Systematic name:
1-alkyl-2-acyl-sn-glycero-3-phosphocholine:1-organyl-2-lyso-sn-glycero-3-phospholipid acetyltransferase

Reaction

Comments:

catalyses the transfer of the acetyl group from 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine (platelet-activating factor) to the sn-2 position of lyso-glycerophospholipids containing ethanolamine, choline, serine, inositol or phosphate groups at the sn-3 position as well as to sphingosine and long-chain fatty alcohols. The organyl group can be alkyl, acyl or alk-1-enyl (sometimes also collectively referred to as 'radyl').

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0047179
CAS Registry Number: 9012-30-0

References

  1. Lee, T.C., Uemura, Y., Snyder, F.
    A novel CoA-independent transacetylase produces the ethanolamine plasmalogen and acyl analogs of platelet-activating factor (PAF) with PAF as the acetate donor in HL-60 cells.
    J. Biol. Chem. 267 : 19992-20001 (1992). [PMID: 1400315]

[EC 2.3.1.149 created 1999]