EC 2.3.1.81 - Aminoglycoside N3-acetyltransferase

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IntEnz Enzyme Nomenclature
EC 2.3.1.81

Names

Accepted name:
aminoglycoside N3-acetyltransferase
Other names:
3'-aminoglycoside acetyltransferase
3-N-aminoglycoside acetyltransferase
aminoglycoside 3-N-acetyltransferase
3-aminoglycoside acetyltransferase
acetyl-CoA:2-deoxystreptamine-antibiotic N3'-acetyltransferase [incorrect]
aminoglycoside N3'-acetyltransferase [incorrect]
Systematic name:
acetyl-CoA:2-deoxystreptamine-antibiotic N3-acetyltransferase

Reaction

Comments:

Different from EC 2.3.1.60 gentamicin N3-acetyltransferase. A wide range of antibiotics containing the 2-deoxystreptamine ring can act as acceptors, including gentamicin, kanamycin, tobramycin, neomycin and apramycin.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0046353
CAS Registry Number: 60120-42-5
UniProtKB/Swiss-Prot: (10) [show] [UniProt]

References

  1. Davies, J. and O'Connor, S.
    Enzymatic modification of aminoglycoside antibiotics: 3-N-Acetyltransferase with broad specificity that determines resistance to the novel aminoglycoside apramycin.
    Antimicrob. Agents Chemother. 14: 69-72 (1978). [PMID: 356726]

[EC 2.3.1.81 created 1984, modified 2015]