EC 2.1.1.133 - Precorrin-4 C11-methyltransferase

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ENZYME: 2.1.1.133


ID   2.1.1.133
DE   Precorrin-4 C(11)-methyltransferase.
AN   Precorrin-3 methylase.
AN   Precorrin-4 C11-methyltransferase.
CA   S-adenosyl-L-methionine + precorrin-4 = S-adenosyl-L-homocysteine +
CA   precorrin-5.
CC   -!- In the aerobic cobalamin biosythesis pathway, four enzymes are
CC       involved in the conversion of precorrin-3A to precorrin-6A.
CC   -!- The first of the four steps is carried out by EC 1.14.13.83 (CobG),
CC       yielding precorrin-3B as the product.
CC   -!- This is followed by three methylation reactions, which introduce a
CC       methyl group at C-17 (CobJ; EC 2.1.1.131), C-11 (CobM; 2.1.1.133) and
CC       C-1 (CobF; EC 2.1.1.152) of the macrocycle, giving rise to precorrin-
CC       4, precorrin-5 and precorrin-6A, respectively.
DR   P9WGB0    , COBM_MYCTO ;  P9WGB1    , COBM_MYCTU ;  Q9HZP9    , COBM_PSEAE ;
DR   O68100    , COBM_RHOCB ;  Q53138    , COBM_RHOER ;  P21922    , COBM_SINSX ;
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