EC 2.1.1.131 - Precorrin-3B C17-methyltransferase

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IntEnz Enzyme Nomenclature
EC 2.1.1.131

Names

Accepted name:
precorrin-3B C17-methyltransferase
Other names:
CobJ
precorrin-3 methyltransferase
precorrin-3B C17-methyltransferase
precorrin-3 methylase
Systematic name:
S-adenosyl-L-methionine:precorrin-3B C17-methyltransferase

Reaction

Comments:

In the aerobic cobalamin biosythesis pathway, four enzymes are involved in the conversion of precorrin-3A to precorrin-6A. The first of the four steps is carried out by EC 1.14.13.83, precorrin-3B synthase (CobG), yielding precorrin-3B as the product. This is followed by three methylation reactions, which introduce a methyl group at C-17 (CobJ; EC 2.1.1.131), C-11 (CobM; EC 2.1.1.133) and C-1 (CobF; EC 2.1.1.152) of the macrocycle, giving rise to precorrin-4, precorrin-5 and precorrin-6A, respectively.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0030789
CAS Registry Number: 152787-64-9
UniProtKB/Swiss-Prot:

References

  1. Scott, A.I., Roessner, C.A., Stolowich, N.J., Spencer, J.B., Min, C. and Ozaki, S.I.
    Biosynthesis of vitamin B12. Discovery of the enzymes for oxidative ring contraction and insertion of the fourth methyl group.
    FEBS Lett. 331: 105-108 (1993). [PMID: 8405386]
  2. Debussche, L., Thibaut, D., Cameron, B., Crouzet, J. and Blanche, F.J.
    Biosynthesis of the corrin macrocycle of coenzyme B12 in Pseudomonas denitrificans.
    J. Bacteriol. 175: 7430-7440 (1993). [PMID: 8226690]

[EC 2.1.1.131 created 1999]