EC - Inositol 4-methyltransferase

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IntEnz Enzyme Nomenclature


Accepted name:
inositol 4-methyltransferase
Other names:
S-adenosyl-L-methionine:myo-inositol 4-O-methyltransferase
myo-inositol 4-O-methyltransferase
myo-inositol 6-O-methyltransferase
Systematic name:
S-adenosyl-L-methionine:1D-myo-inositol 4-methyltransferase



The enzyme from the rice bean Vigna umbellata (Fabaceae) is highly specific for S-adenosyl-L-methionine. The enzyme also methylates 1L-1,2,4/3,5-cyclohexanepentol, 2,4,6/3,5-pentahydroxycyclohexanone, D,L-2,3,4,6/5-pentacyclohexanone and 2,2'-anhydro-2-C-hydroxymethyl-myo-inositol, but at lower rates than that of myo-inositol.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0030787
CAS Registry Numbers: 146048-86-4 169277-48-9 (from EC


  1. Vernon, D.M. and Bohnert, H.J.
    A novel methyl transferase induced by osmotic stress in the facultative halophyte Mesembryanthemum crystallinum.
    EMBO J. 11: 2077-2085 (1992). [PMID: 1600940]
  2. Wanek, W. and Richter, A.
    Purification and characterization of myo-inositol 6-O-methyltransferase from Vigna umbellata Ohwi et Ohashi.
    Planta 197: 427-434 (1995).

[EC created 1999 (EC created 1999, incorporated 2002), modified 2002]