EC - (RS)-norcoclaurine 6-O-methyltransferase

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IntEnz Enzyme Nomenclature


Accepted name:
(RS)-norcoclaurine 6-O-methyltransferase
Systematic name:
S-adenosyl-L-methionine:(RS)-norcoclaurine 6-O-methyltransferase



The enzyme will also catalyse the 6-O-methylation of (RS)-norlaudanosoline to form 6-O-methyl-norlaudanosoline, but this alkaloid has not been found to occur in plants.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ERGO , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0030786
CAS Registry Numbers: 167398-06-3 89700-33-4


  1. Rueffer, M., Nagakura, N. and Zenk, M.H.
    Partial purification and properties of S-adenosyl-L-methionine:(R),(S)-norlaudanosoline-6-O-methyltransferase from Argemone platyceras cell cultures.
    Planta Med. 49 : 131-137 (1983). [PMID: 17405035]
  2. Sato, F., Tsujita, T., Katagiri, Y., Yoshida, S. and Yamada, Y.
    Purification and characterization of S-adenosyl-L-methionine:norcoclaurine-6-O-methyltransferase from cultured Coptis japonica cells.
    Eur. J. Biochem. 225 : 125-131 (1994). [PMID: 7925429]
  3. Stadler, R. and Zenk, M.H.
    A revision of the generally accepted pathway for the biosynthesis of the benzyltetrahydroisoquinoline reticuline.
    Liebigs Ann. Chem. 555-562 (1990).

[EC created 1999]