EC 2.1.1.115 - (RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline N-methyltransferase

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IntEnz Enzyme Nomenclature
EC 2.1.1.115

Names

Accepted name:
(RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline N-methyltransferase
Other name:
norreticuline N-methyltransferase
Systematic name:
S-adenosyl-L-methionine:(RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline N-methyltransferase

Reaction

Comments:

Broad substrate specificity for (RS)-1-benzyl-1,2,3,4-tetrahydroisoquinolines; including coclaurine, norcoclaurine, isococlaurine, norarmepavine, norreticuline and tetrahydropapaverine. Both R- and S-enantiomers are methylated. The enzyme participates in the pathway leading to benzylisoquinoline alkaloid synthesis in plants. The physiological substrate is likely to be coclaurine. The enzyme was earlier termed norreticuline N-methyltransferase. However, norreticuline has not been found to occur in nature and that name does not reflect the broad specificity of the enzyme for (RS)-1-benzyl-1,2,3,4-tetrahydroisoquinolines.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ERGO , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0030776
CAS Registry Number: 132084-82-3

References

  1. Frenzel, T. and Zenk, M.H.
    Purification and characterization of three isoforms of S-adenosyl-L-methionine:(R,S)-tetrahydrobenzyl-isoquinoline N-methyltransferase from Berberis koetineana cell cultures.
    Phytochemistry 29: 3491-3497 (1990).

[EC 2.1.1.115 created 1999]