EC 1.3.1.124 - 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing]

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ENZYME: 1.3.1.124


ID   1.3.1.124
DE   2,4-dienoyl-CoA reductase ((3E)-enoyl-CoA-producing).
AN   Delta(2),Delta(4)-dienoyl-CoA reductase.
CA   (1) A (3E)-3-enoyl-CoA + NADP(+) = a (2E,4E)-2,4-dienoyl-CoA + NADPH.
CA   (2) A (3E)-3-enoyl-CoA + NADP(+) = a (2E,4Z)-2,4-dienoyl-CoA + NADPH.
CC   -!- This enzyme, characterized from eukaryotic organisms, catalyzes the
CC       reduction of either (2E,4E)-2,4-dienoyl-CoA or (2E,4Z)-2,4-dienoyl-
CC       CoA to (3E)-3-enoyl-CoA.
CC   -!- The best substrates for the enzyme from bovine liver have a chain-
CC       length of 8 or 10.
CC   -!- Mammals possess both mitochondrial and peroxisomal variants of this
CC       enzyme.
CC   -!- Cf. EC 1.3.1.34.
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