EC - 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing]

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IntEnz Enzyme Nomenclature


Accepted name:
2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing]
Other name:
Δ24-dienoyl-CoA reductase
Systematic name:
(3E)-3-enoyl-CoA:NADP+ 4-oxidoreductase



This enzyme, characterized from eukaryotic organisms, catalyses the reduction of either (2E,4E)-2,4-dienoyl-CoA or (2E,4Z)-2,4-dienoyl-CoA to (3E)-3-enoyl-CoA. The best substrates for the enzyme from bovine liver have a chain-length of 8 or 10. Mammals possess both mitochondrial and peroxisomal variants of this enzyme. cf. EC, 2,4-dienoyl-CoA reductase [(2E)-enoyl-CoA-producing].

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
UniProtKB/Swiss-Prot: (15) [show] [UniProt]


  1. Kunau, W. H., Dommes, P.
    Degradation of unsaturated fatty acids. Identification of intermediates in the degradation of cis-4-decenoly-CoA by extracts of beef-liver mitochondria.
    Eur. J. Biochem. 91 : 533-544 (1978). [PMID: 729581]
  2. Dommes, V., Luster, W., Cvetanovi?, M., Kunau, W. H.
    Purification by affinity chromatography of 2,4-dienoyl-CoA reductases from bovine liver and Escherichia coli.
    Eur. J. Biochem. 125 : 335-341 (1982). [PMID: 6749495]
  3. Gurvitz, A., Rottensteiner, H., Kilpelainen, S. H., Hartig, A., Hiltunen, J. K., Binder, M., Dawes, I. W., Hamilton, B.
    The Saccharomyces cerevisiae peroxisomal 2,4-dienoyl-CoA reductase is encoded by the oleate-inducible gene SPS19.
    J. Biol. Chem. 272 : 22140-22147 (1997). [PMID: 9268358]
  4. Geisbrecht, B. V., Liang, X., Morrell, J. C., Schulz, H., Gould, S. J.
    The mouse gene PDCR encodes a peroxisomal delta(2), delta(4)-dienoyl-CoA reductase.
    J. Biol. Chem. 274 : 25814-25820 (1999). [PMID: 10464321]
  5. De Nys, K., Meyhi, E., Mannaerts, G. P., Fransen, M., Van Veldhoven, P. P.
    Characterisation of human peroxisomal 2,4-dienoyl-CoA reductase.
    Biochim. Biophys. Acta 1533 : 66-72 (2001). [PMID: 11514237]
  6. Alphey, M. S., Yu, W., Byres, E., Li, D., Hunter, W. N.
    Structure and reactivity of human mitochondrial 2,4-dienoyl-CoA reductase: enzyme-ligand interactions in a distinctive short-chain reductase active site.
    J. Biol. Chem. 280 : 3068-3077 (2005). [PMID: 15531764]

[EC created 2020]