EC - 4-amino-4-deoxychorismate mutase

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IntEnz Enzyme Nomenclature


Accepted name:
4-amino-4-deoxychorismate mutase
Systematic name:
4-amino-4-deoxychorismate pyruvatemutase



The enzyme, characterized from the bacteria Streptomyces venezuelae and Streptomyces pristinaespiralis, participates in the biosynthesis of the antibiotics chloramphenicol and pristinamycin IA, respectively. cf. EC, chorismate mutase.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB


  1. Blanc, V., Gil, P., Bamas-Jacques, N., Lorenzon, S., Zagorec, M., Schleuniger, J., Bisch, D., Blanche, F., Debussche, L., Crouzet, J., Thibaut, D.
    Identification and analysis of genes from Streptomyces pristinaespiralis encoding enzymes involved in the biosynthesis of the 4-dimethylamino-L-phenylalanine precursor of pristinamycin I.
    Mol. Microbiol. 23 : 191-202 (1997). [PMID: 9044253]
  2. He, J., Magarvey, N., Piraee, M., Vining, L. C.
    The gene cluster for chloramphenicol biosynthesis in Streptomyces venezuelae ISP5230 includes novel shikimate pathway homologues and a monomodular non-ribosomal peptide synthetase gene.
    Microbiology (Reading, Engl.) 147 : 2817-2829 (2001). [PMID: 11577160]

[EC created 2019]