EC - Phosphatidyl-N-methylethanolamine N-methyltransferase

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IntEnz Enzyme Nomenclature


Accepted name:
phosphatidyl-N-methylethanolamine N-methyltransferase
Other names:
methyltransferase II
phosphatidyl-N-methylethanolamine methyltransferase
phosphatidyl-N-monomethylethanolamine methyltransferase
phosphatidylethanolamine methyltransferase I
phosphatidylmonomethylethanolamine methyltransferase
phospholipid methyltransferase
Systematic name:
S-adenosyl-L-methionine:phosphatidyl-N-methylethanolamine N-methyltransferase



The enzyme also catalyses the transfer of a further methyl group, producing phosphatidylcholine.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ERGO , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0080101 , GO:0000773
CAS Registry Number: 67167-73-1
UniProtKB/Swiss-Prot: (11) [show] [UniProt]


  1. Hirata, F., Viveros, O.H., Diliberto, E.J., Jr. and Axelrod, J.
    Identification and properties of two methyltransferases in conversion of phosphatidylethanolamine to phosphatidylcholine.
    Proc. Natl. Acad. Sci. USA 75: 1718-1721 (1978). [PMID: 25437]
  2. Schneider, W.J. and Vance, D.E.
    Conversion of phosphatidylethanolamine to phosphatidylcholine in rat liver. Partial purification and characterization of the enzymatic activities.
    J. Biol. Chem. 254: 3886-3891 (1979). [PMID: 438165]

[EC created 1984]