EC - Glutarate dioxygenase

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IntEnz Enzyme Nomenclature


Accepted name:
glutarate dioxygenase
Systematic name:
glutarate,2-oxoglutarate:oxygen oxidoreductase ((S)-2-hydroxyglutarate-forming)



Requires iron(II). The enzyme, characterized from the bacteria Escherichia coli and Pseudomonas putida, participates in L-lysine degradation in many bacteria. It provides an alternative route for L-glutarate degradation that does not proceed via CoA-activated intermediates.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB


  1. Knorr, S., Sinn, M., Galetskiy, D., Williams, R. M., Wang, C., Muller, N., Mayans, O., Schleheck, D., Hartig, J. S.
    Widespread bacterial lysine degradation proceeding via glutarate and L-2-hydroxyglutarate.
    Nat Commun 9: 5071 (2018). [PMID: 30498244]
  2. Zhang, M., Gao, C., Guo, X., Guo, S., Kang, Z., Xiao, D., Yan, J., Tao, F., Zhang, W., Dong, W., Liu, P., Yang, C., Ma, C., Xu, P.
    Increased glutarate production by blocking the glutaryl-CoA dehydrogenation pathway and a catabolic pathway involving L-2-hydroxyglutarate.
    Nat Commun 9: 2114 (2018). [PMID: 29844506]

[EC created 2019]