EC 1.14.11.64 - Glutarate dioxygenase

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IntEnz Enzyme Nomenclature
EC 1.14.11.64

Names

Accepted name:
glutarate dioxygenase
Systematic name:
glutarate,2-oxoglutarate:oxygen oxidoreductase ((S)-2-hydroxyglutarate-forming)

Reaction

Comments:

Requires iron(II). The enzyme, characterized from the bacteria Escherichia coli and Pseudomonas putida, participates in L-lysine degradation in many bacteria. It provides an alternative route for L-glutarate degradation that does not proceed via CoA-activated intermediates.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB

References

  1. Knorr, S., Sinn, M., Galetskiy, D., Williams, R. M., Wang, C., Muller, N., Mayans, O., Schleheck, D., Hartig, J. S.
    Widespread bacterial lysine degradation proceeding via glutarate and L-2-hydroxyglutarate.
    Nat Commun 9: 5071 (2018). [PMID: 30498244]
  2. Zhang, M., Gao, C., Guo, X., Guo, S., Kang, Z., Xiao, D., Yan, J., Tao, F., Zhang, W., Dong, W., Liu, P., Yang, C., Ma, C., Xu, P.
    Increased glutarate production by blocking the glutaryl-CoA dehydrogenation pathway and a catabolic pathway involving L-2-hydroxyglutarate.
    Nat Commun 9: 2114 (2018). [PMID: 29844506]

[EC 1.14.11.64 created 2019]