EC - MRNA (2'-O-methyladenosine-N6-)-methyltransferase

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IntEnz Enzyme Nomenclature


Accepted name:
mRNA (2'-O-methyladenosine-N6-)-methyltransferase
Other names:
messenger ribonucleate 2'-O-methyladenosine NG-methyltransferase
S-adenosyl-L-methionine:mRNA (2'-O-methyladenosine-6-N-)-methyltransferase
Systematic name:
S-adenosyl-L-methionine:mRNA (2'-O-methyladenosine-N6-)-methyltransferase



mRNA containing an N6,2'-O-dimethyladenosine cap.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Protein domains and families: PROSITE:PDOC51143
Structural data: CSA , EC2PDB
Gene Ontology: GO:0016422
CAS Registry Number: 68009-87-0


  1. Keith, J.M., Ensinger, M.J. and Moss, B.
    HeLa cell RNA (2'-O-methyladenosine-N6-)-methyltransferase specific for the capped 5'-end of messenger RNA.
    J. Biol. Chem. 253: 5033-5039 (1978). [PMID: 670176]
  2. Mauer, J., Luo, X., Blanjoie, A., Jiao, X., Grozhik, A. V., Patil, D. P., Linder, B., Pickering, B. F., Vasseur, J. J., Chen, Q., Gross, S. S., Elemento, O., Debart, F., Kiledjian, M., Jaffrey, S. R.
    Reversible methylation of m6Am in the 5' cap controls mRNA stability.
    Nature 541: 371-375 (2017). [PMID: 28002401]

[EC created 1982]