EC - 4-hydroxybutyrate—CoA ligase (ADP-forming)

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IntEnz Enzyme Nomenclature


Accepted name:
4-hydroxybutyrate—CoA ligase (ADP-forming)
Systematic name:
4-hydroxybutanoate:CoA ligase (ADP-forming)



The enzyme, characterized from the marine ammonia-oxidizing archaeon Nitrosopumilus maritimus, participates in a variant of the 3-hydroxypropanoate/4-hydroxybutanate CO2 fixation cycle. cf. EC, 4-hydroxybutyrate—CoA ligase (AMP-forming).

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB


  1. Konneke, M., Schubert, D. M., Brown, P. C., Hugler, M., Standfest, S., Schwander, T., Schada von Borzyskowski, L., Erb, T. J., Stahl, D. A., Berg, I. A.
    Ammonia-oxidizing archaea use the most energy-efficient aerobic pathway for CO2 fixation.
    Proc. Natl. Acad. Sci. U.S.A. 111: 8239-8244 (2014). [PMID: 24843170]

[EC created 2019]