EC - Peptidyl-lysine (3S)-dioxygenase

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IntEnz Enzyme Nomenclature


Accepted name:
peptidyl-lysine (3S)-dioxygenase
Other names:
Jumonji domain-containing protein 7
JmjC domain-containing protein 7
Systematic name:
[protein]-L-lysine,2-oxoglutarate:oxygen oxidoreductase (3S-hydroxylating)



Requires iron(II). The enzyme acts on specific lysine residues in its substrates, and is stereo-specific. The enzyme encoded by the human JMJD7 gene acts specifically on two related members of the translation factor family of GTPases, DRG1 and DRG2.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB


  1. Markolovic, S., Zhuang, Q., Wilkins, S. E., Eaton, C. D., Abboud, M. I., Katz, M. J., McNeil, H. E., Le?niak, R. K., Hall, C., Struwe, W. B., Konietzny, R., Davis, S., Yang, M., Ge, W., Benesch, J. L. P., Kessler, B. M., Ratcliffe, P. J., Ratcliffe, P. J., Cockman, M. E., Fischer, R., Wappner, P., Chowdhury, R., Coleman, M. L., Schofield, C. J.
    The Jumonji-C oxygenase JMJD7 catalyzes (3S)-lysyl hydroxylation of TRAFAC GTPases.
    Nat. Chem. Biol. 14: 688-695 (2018). [PMID: 29915238]

[EC created 2019]