EC - Indolepyruvate C-methyltransferase

  IntEnz view ENZYME view

IntEnz Enzyme Nomenclature


Accepted name:
indolepyruvate C-methyltransferase
Other names:
indolepyruvate 3-methyltransferase
indolepyruvate methyltransferase
indolepyruvic acid methyltransferase
S-adenosyl-L-methionine:indolepyruvate C-methyltransferase
ind1 (gene name)
Systematic name:
S-adenosyl-L-methionine:(indol-3-yl)pyruvate C3-methyltransferase



The enzyme, characterized from the bacterium Streptomyces griseus, is involved in the biosynthesis of the antibacterial drug indolmycin.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0030747
CAS Registry Number: 54576-88-4


  1. Hornemann, U., Speedie, M.K., Hurley, L.H. and Floss, H.G.
    Demonstration of a C-methylating enzyme in cell free extracts of indolmycin-producing Streptomyces griseus.
    Biochem. Biophys. Res. Commun. 39: 594-599 (1970). [PMID: 5490210]
  2. Hornemann, U., Hurley, L. H., Speedie, M. K., Floss, H. G.
    The biosynthesis of indolmycin.
    J. Am. Chem. Soc. 93: 3028-3035 (1971). [PMID: 5095271]
  3. Speedie, M. K., Hornemann, U., Floss, H. G.
    Isolation and characterization of tryptophan transaminase and indolepyruvate C-methyltransferase. Enzymes involved in indolmycin biosynthesis in Streptomyces griseus.
    J. Biol. Chem. 250: 7819-7825 (1975). [PMID: 809439]
  4. Du, Y. L., Alkhalaf, L. M., Ryan, K. S.
    In vitro reconstitution of indolmycin biosynthesis reveals the molecular basis of oxazolinone assembly.
    Proc. Natl. Acad. Sci. U.S.A. 112: 2717-2722 (2015). [PMID: 25730866]

[EC created 1976, modified 2016]