EC 7.6.2.4 - ABC-type fatty-acyl-CoA transporter

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IntEnz Enzyme Nomenclature
EC 7.6.2.4

Names

Accepted name:
ABC-type fatty-acyl-CoA transporter
Other name:
fatty-acyl-CoA-transporting ATPase
Systematic name:
ATP phosphohydrolase (ABC-type, fatty-acyl-CoA-transporting)

Reaction

Comments:

An ATP-binding cassette (ABC) type transporter, characterized by the presence of two similar ATP-binding domains/proteins and two integral membrane domains/proteins. Does not undergo phosphorylation during the transport process. An animal and yeast enzyme that transports fatty acyl CoA into and out of peroxisomes. In humans, it is associated with Zellweger's syndrome. Formerly EC 3.6.3.47.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Protein domains and families: PROSITE:PDOC00185
Structural data: CSA , EC2PDB
UniProtKB/Swiss-Prot:

References

  1. Kamijo, K., Taketani, S., Yokota, S., Osumi, T. and Hashimoto, T.
    The 70-kDa peroxisomal membrane protein is a member of the Mdr (P-glcoprotein)-related ATP-binding protein superfamily.
    J. Biol. Chem. 265: 4534-4540 (1990). [PMID: 1968461]
  2. Hettema, E.H., van Roermund, C.W.T., Distel, B., van den Berg. M., Vilela, C., Rodrigues-Posada, C., Wanders, R.J.A. and Tabak, H.F.
    The ABC transporter proteins Pat1 and Pat2 are required for import of long-chain fatty acids into peroxisomes of Saccharomyces cerevisiae.
    EMBO J. 15: 3813-3822 (1996). [PMID: 8670886]
  3. Saier, M.H., Jr.
    Molecular phylogeny as a basis for the classification of transport proteins from bacteria, archaea and eukarya.
    Adv. Microb. Physiol. 40: 81-136 (1998). [PMID: 9889977]

[EC 7.6.2.4 created 2000 as EC 3.6.3.47, transferred 2018 to EC 7.6.2.4]