EC 7.6.2.8 - ABC-type vitamin B12 transporter

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IntEnz Enzyme Nomenclature
EC 7.6.2.8

Names

Accepted name:
ABC-type vitamin B12 transporter
Other names:
BtuCDF
vitamin B12 ABC transporter
vitamin B12-transporting ATPase
Systematic name:
ATP phosphohydrolase (ABC-type, vitamin B12-importing)

Reaction

Comments:

An ATP-binding cassette (ABC) type transporter, characterized by the presence of two similar ATP-binding domains/proteins and two integral membrane domains/proteins. Does not undergo phosphorylation during the transport process. A bacterial enzyme that interacts with an extracytoplasmic substrate binding protein and mediates the high affinity uptake of cobalamin derivatives. Formerly EC 3.6.3.33.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Protein domains and families: PROSITE:PDOC00185
Structural data: CSA , EC2PDB
Gene Ontology: GO:0015420
UniProtKB/Swiss-Prot: (52) [show] [UniProt]

References

  1. Kuan, G., Dassa, E., Saurin, N., Hofnung, M. and Saier, M.H., Jr.
    Phylogenetic analyses of the ATP-binding constituents of bacterial extracytoplasmic receptor-dependent ABC-type nutrient uptake permeases.
    Res. Microbiol. 146: 271-278 (1995). [PMID: 7569321]
  2. Saier, M.H., Jr.
    Molecular phylogeny as a basis for the classification of transport proteins from bacteria, archaea and eukarya.
    Adv. Microb. Physiol. 40: 81-136 (1998). [PMID: 9889977]
  3. Friedrich, M.J., de Veaux, L.C. and Kadner, R.J.
    Nucleotide sequence of the btuCED genes involved in vitamin B12 transport in Escherichia coli and homology with components of periplasmic-binding-protein-dependent transport systems.
    J. Bacteriol. 167: 928-934 (1986). [PMID: 3528129]

[EC 7.6.2.8 created 2000 as EC 3.6.3.33, transferred 2018 to EC 7.6.2.8]