EC - P-type Ca2+ transporter

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IntEnz Enzyme Nomenclature


Accepted name:
P-type Ca2+ transporter
Other names:
Ca2+-pumping ATPase
calcium pump
plasma membrane Ca-ATPase
sarco(endo)plasmic reticulum Ca2+-ATPase
sarcoplasmic reticulum ATPase
calcium-translocating P-type ATPase
Ca2+-transporting ATPase
Systematic name:
ATP phosphohydrolase (P-type, Ca2+-transporting)




A P-type ATPase that undergoes covalent phosphorylation during the transport cycle. This enzyme family comprises three types of Ca2+-transporting enzymes that are found in the plasma membrane, the sarcoplasmic reticulum, in yeast, and in some bacteria. The enzymes from plasma membrane and from yeast have been shown to transport one ion per ATP hydrolysed whereas those from the sarcoplasmic reticulum transport two ions per ATP hydrolysed. In muscle cells Ca2+ is transported from the cytosol into the sarcoplasmic reticulum. Formerly EC and EC

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Protein domains and families: PROSITE:PDOC00139
Structural data: CSA , EC2PDB
Gene Ontology: GO:0005388
UniProtKB/Swiss-Prot: (92) [show] [UniProt]


  1. Schatzmann, H.J. and Vicenzi, F.F.
    Calcium movements across the membrane of human red cells.
    J. Physiol. 201: 369-395 (1969). [PMID: 4238381]
  2. Inesi, G., Watanabe, T., Coan, C. and Murphy, A.
    The mechanism of sarcoplasmic reticulum ATPase.
    Ann. NY Acad. Sci. 402: 515-532 (1982). [PMID: 6301340]
  3. Carafoli, E.
    The Ca2+ pump of the plasma membrane.
    J. Biol. Chem. 267: 2115-2118 (1992). [PMID: 1310307]
  4. MacLennan, D.H., Rice, W.J. and Green, N.M.
    The mechanism of Ca2+ transport by sarco(endo)plasmic reticulum Ca2+-ATPases.
    J. Biol. Chem. 272: 28815-28818 (1997). [PMID: 9360942]
  5. Toyoshima, C., Nakasako, M., Nomura, H., Ogawa, H.
    Crystal structure of the calcium pump of sarcoplasmic reticulum at 2.6 A resolution.
    Nature 405: 647-655 (2000). [PMID: 10864315]
  6. Andersen, J. L., Gourdon, P., Moller, J. V., Morth, J. P., Nissen, P.
    Crystallization and preliminary structural analysis of the Listeria monocytogenes Ca(2+)-ATPase LMCA1.
    Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 67: 718-722 (2011). [PMID: 21636921]

[EC created 1984 as as EC, transferred 2000 to EC, modified 2001, modified 2011, transferred 2018 to EC]