EC - L-cysteine S-thiosulfotransferase

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IntEnz Enzyme Nomenclature


Accepted name:
L-cysteine S-thiosulfotransferase
Other name:
Systematic name:
thiosulfate:[SoxY protein]-L-cysteine thiosufotransferase



The enzyme is part of the Sox enzyme system, which participates in a bacterial thiosulfate oxidation pathway that produces sulfate. It catalyses two reactions in the pathway - early in the pathway it attaches a thiosulfate molecule to the sulfur atom of an L-cysteine of a SoxY protein; later it transfers a second thiosulfate molecule to a sulfane group that is already attached to the same cysteine residue.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
UniProtKB/Swiss-Prot: (10) [show] [UniProt]


  1. Friedrich, C. G., Quentmeier, A., Bardischewsky, F., Rother, D., Kraft, R., Kostka, S., Prinz, H.
    Novel genes coding for lithotrophic sulfur oxidation of Paracoccus pantotrophus GB17.
    J. Bacteriol. 182: 4677-4687 (2000). [PMID: 10940005]
  2. Cheesman, M. R., Little, P. J., Berks, B. C.
    Novel heme ligation in a c-type cytochrome involved in thiosulfate oxidation: EPR and MCD of SoxAX from Rhodovulum sulfidophilum.
    Biochemistry 40: 10562-10569 (2001). [PMID: 11523998]
  3. Rother, D., Friedrich, C. G.
    The cytochrome complex SoxXA of Paracoccus pantotrophus is produced in Escherichia coli and functional in the reconstituted sulfur-oxidizing enzyme system.
    Biochim. Biophys. Acta 1598: 65-73 (2002). [PMID: 12147345]
  4. Bamford, V. A., Bruno, S., Rasmussen, T., Appia-Ayme, C., Cheesman, M. R., Berks, B. C., Hemmings, A. M.
    Structural basis for the oxidation of thiosulfate by a sulfur cycle enzyme.
    EMBO J. 21: 5599-5610 (2002). [PMID: 12411478]
  5. Dambe, T., Quentmeier, A., Rother, D., Friedrich, C., Scheidig, A. J.
    Structure of the cytochrome complex SoxXA of Paracoccus pantotrophus, a heme enzyme initiating chemotrophic sulfur oxidation.
    J. Struct. Biol. 152: 229-234 (2005). [PMID: 16297640]
  6. Hensen, D., Sperling, D., Truper, H. G., Brune, D. C., Dahl, C.
    Thiosulphate oxidation in the phototrophic sulphur bacterium Allochromatium vinosum.
    Mol. Microbiol. 62: 794-810 (2006). [PMID: 16995898]
  7. Grabarczyk, D. B., Berks, B. C.
    Intermediates in the Sox sulfur oxidation pathway are bound to a sulfane conjugate of the carrier protein SoxYZ.
    PLoS ONE 12: e0173395 (2017). [PMID: 28257465]

[EC created 2018]