EC 2.8.5.2 - L-cysteine S-thiosulfotransferase

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IntEnz Enzyme Nomenclature
EC 2.8.5.2

Names

Accepted name:
L-cysteine S-thiosulfotransferase
Other name:
SoxXA
Systematic name:
thiosulfate:[SoxY protein]-L-cysteine thiosufotransferase

Reactions

Comments:

The enzyme is part of the Sox enzyme system, which participates in a bacterial thiosulfate oxidation pathway that produces sulfate. It catalyses two reactions in the pathway - early in the pathway it attaches a thiosulfate molecule to the sulfur atom of an L-cysteine of a SoxY protein; later it transfers a second thiosulfate molecule to a sulfane group that is already attached to the same cysteine residue.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
UniProtKB/Swiss-Prot: (10) [show] [UniProt]

References

  1. Friedrich, C. G., Quentmeier, A., Bardischewsky, F., Rother, D., Kraft, R., Kostka, S., Prinz, H.
    Novel genes coding for lithotrophic sulfur oxidation of Paracoccus pantotrophus GB17.
    J. Bacteriol. 182: 4677-4687 (2000). [PMID: 10940005]
  2. Cheesman, M. R., Little, P. J., Berks, B. C.
    Novel heme ligation in a c-type cytochrome involved in thiosulfate oxidation: EPR and MCD of SoxAX from Rhodovulum sulfidophilum.
    Biochemistry 40: 10562-10569 (2001). [PMID: 11523998]
  3. Rother, D., Friedrich, C. G.
    The cytochrome complex SoxXA of Paracoccus pantotrophus is produced in Escherichia coli and functional in the reconstituted sulfur-oxidizing enzyme system.
    Biochim. Biophys. Acta 1598: 65-73 (2002). [PMID: 12147345]
  4. Bamford, V. A., Bruno, S., Rasmussen, T., Appia-Ayme, C., Cheesman, M. R., Berks, B. C., Hemmings, A. M.
    Structural basis for the oxidation of thiosulfate by a sulfur cycle enzyme.
    EMBO J. 21: 5599-5610 (2002). [PMID: 12411478]
  5. Dambe, T., Quentmeier, A., Rother, D., Friedrich, C., Scheidig, A. J.
    Structure of the cytochrome complex SoxXA of Paracoccus pantotrophus, a heme enzyme initiating chemotrophic sulfur oxidation.
    J. Struct. Biol. 152: 229-234 (2005). [PMID: 16297640]
  6. Hensen, D., Sperling, D., Truper, H. G., Brune, D. C., Dahl, C.
    Thiosulphate oxidation in the phototrophic sulphur bacterium Allochromatium vinosum.
    Mol. Microbiol. 62: 794-810 (2006). [PMID: 16995898]
  7. Grabarczyk, D. B., Berks, B. C.
    Intermediates in the Sox sulfur oxidation pathway are bound to a sulfane conjugate of the carrier protein SoxYZ.
    PLoS ONE 12: e0173395 (2017). [PMID: 28257465]

[EC 2.8.5.2 created 2018]