IntEnz

EC 2.1.1.28 - Phenylethanolamine N-methyltransferase

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IntEnz Enzyme Nomenclature
EC 2.1.1.28

Names

Accepted name:

phenylethanolamine N-methyltransferase

Other names:

noradrenalin N-methyltransferase
noradrenaline N-methyltransferase
norepinephrine N-methyltransferase
norepinephrine methyltransferase
phenethanolamine N-methyltransferase
phenethanolamine methyltransferase

Systematic name:

S-adenosyl-L-methionine:phenylethanolamine N-methyltransferase

Reactions

12176 [IUBMB]

phenylethanolamine

phenylethanolamine

Name origin: UniProt - CHECKED (C)

CHEBI:57741

Formula: C8H12NO
Charge: 1

ChEBI compound status: CHECKED (C)

+

S-adenosyl-L-methionine

S-adenosyl-L-methionine

Name origin: UniProt - CHECKED (C)

CHEBI:59789

Formula: C15H23N6O5S
Charge: 1

ChEBI compound status: CHECKED (C)

=

H⁺

H(+)

Name origin: UniProt - CHECKED (C)

CHEBI:15378

Formula: H
Charge: 1

ChEBI compound status: CHECKED (C)

+

N-methylphenylethanolamine

N-methylphenylethanolamine

Name origin: UniProt - CHECKED (C)

CHEBI:57946

Formula: C9H14NO
Charge: 1

ChEBI compound status: CHECKED (C)

+

S-adenosyl-L-homocysteine

S-adenosyl-L-homocysteine

Name origin: UniProt - CHECKED (C)

CHEBI:57856

Formula: C14H20N6O5S
Charge: 0

ChEBI compound status: CHECKED (C)
25269

(R)-noradrenaline

(R)-noradrenaline

Name origin: UniProt - CHECKED (C)

CHEBI:72587

Formula: C8H12NO3
Charge: 1

ChEBI compound status: CHECKED (C)

+

S-adenosyl-L-methionine

S-adenosyl-L-methionine

Name origin: UniProt - CHECKED (C)

CHEBI:59789

Formula: C15H23N6O5S
Charge: 1

ChEBI compound status: CHECKED (C)

=

(R)-adrenaline

(R)-adrenaline

Name origin: UniProt - CHECKED (C)

CHEBI:71406

Formula: C9H14NO3
Charge: 1

ChEBI compound status: CHECKED (C)

+

H⁺

H(+)

Name origin: UniProt - CHECKED (C)

CHEBI:15378

Formula: H
Charge: 1

ChEBI compound status: CHECKED (C)

+

S-adenosyl-L-homocysteine

S-adenosyl-L-homocysteine

Name origin: UniProt - CHECKED (C)

CHEBI:57856

Formula: C14H20N6O5S
Charge: 0

ChEBI compound status: CHECKED (C)

Comments:

Acts on various phenylethanolamines; converts noradrenaline into adrenaline.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway

Protein domains and families: PROSITE:PDOC00844

Structural data: CSA , EC2PDB

Gene Ontology: GO:0004603

CAS Registry Number: 9037-68-7

UniProtKB/Swiss-Prot:

P10938

PNMT_BOVIN

P11086

PNMT_HUMAN

P40935

PNMT_MOUSE

Q06AU9

PNMT_PIG

P10937

PNMT_RAT

References

Axelrod, J.

Purification and properties of phenylethanolamine-N-methyl transferase.

J. Biol. Chem. 237 : 1657-1660 (1962).
Connett, R.J. and Kirschner, N.

Purification and properties of bovine phenylethanolamine N-methyltransferase.

J. Biol. Chem. 245 : 329-334 (1970). [PMID: 5412063]

[EC 2.1.1.28 created 1972]

EC 2 - Transferases