EC - 8-dimethylallylnaringenin 2'-hydroxylase

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IntEnz Enzyme Nomenclature


Accepted name:
8-dimethylallylnaringenin 2'-hydroxylase
Other name:
8-DMAN 2'-hydroxylase
Systematic name:
sophoraflavanone-B,[reduced NADPH—hemoprotein reductase]:oxygen oxidoreductase (2'-hydroxylating)




A membrane-bound cytochrome P450 (heme-thiolate) protein that is associated with the endoplasmic reticulum [1,2]. This enzyme is specific for sophoraflavanone B as substrate. Along with EC (naringenin 8-dimethylallyltransferase) and EC (leachianone G 2''-dimethylallyltransferase), this enzyme forms part of the sophoraflavanone G biosynthetic pathway.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB


  1. Yamamoto, H., Yatou, A. and Inoue, K.
    8-Dimethylallylnaringenin 2'-hydroxylase, the crucial cytochrome P450 mono-oxygenase for lavandulylated flavanone formation in Sophora flavescens cultured cells.
    Phytochemistry 58: 671-676 (2001). [PMID: 11672730]
  2. Zhao, P., Inoue, K., Kouno, I. and Yamamoto, H.
    Characterization of leachianone G 2''-dimethylallyltransferase, a novel prenyl side-chain elongation enzyme for the formation of the lavandulyl group of sophoraflavanone G in Sophora flavescens Ait. cell suspension cultures.
    Plant Physiol. 133: 1306-1313 (2003). [PMID: 14551337]

[EC created 2007 as EC, transferred 2018 to EC]