EC - 5-O-(4-coumaroyl)-D-quinate 3'-monooxygenase

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IntEnz Enzyme Nomenclature


Accepted name:
5-O-(4-coumaroyl)-D-quinate 3'-monooxygenase
Other names:
5-O-(4-coumaroyl)-D-quinate/shikimate 3'-hydroxylase
coumaroylquinate(coumaroylshikimate) 3'-monooxygenase
Systematic name:
trans-5-O-(4-coumaroyl)-D-quinate,[reduced NADPH—hemoprotein reductase]:oxygen oxidoreductase (3'-hydroxylating)



A cytochrome P450 (heme-thiolate) protein, found in plants. It also acts on trans-5-O-(4-coumaroyl)shikimate. Formerly EC

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ERGO , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
CAS Registry Number: 112131-08-5


  1. Kühnl, T., Koch, U., Heller, W. and Wellman, E.
    Chlorogenic acid biosynthesis: characterization of a light-induced microsomal 5-O-(4-coumaroyl)-D-quinate/shikimate 3'-hydroxylase from carrot (Daucus carota L.) cell suspension cultures.
    Arch. Biochem. Biophys. 258: 226-232 (1987). [PMID: 2821918]
  2. Schoch, G., Goepfert, S., Morant, M., Hehn, A., Meyer, D., Ullmann, P., Werck-Reichhart, D.
    CYP98A3 from Arabidopsis thaliana is a 3'-hydroxylase of phenolic esters, a missing link in the phenylpropanoid pathway.
    J. Biol. Chem. 276: 36566-36574 (2001). [PMID: 11429408]
  3. Franke, R., Humphreys, J. M., Hemm, M. R., Denault, J. W., Ruegger, M. O., Cusumano, J. C., Chapple, C.
    The Arabidopsis REF8 gene encodes the 3-hydroxylase of phenylpropanoid metabolism.
    Plant J. 30: 33-45 (2002). [PMID: 11967091]
  4. Matsuno, M., Compagnon, V., Schoch, G. A., Schmitt, M., Debayle, D., Bassard, J. E., Pollet, B., Hehn, A., Heintz, D., Ullmann, P., Lapierre, C., Bernier, F., Ehlting, J., Werck-Reichhart, D.
    Evolution of a novel phenolic pathway for pollen development.
    Science 325: 1688-1692 (2009). [PMID: 19779199]

[EC created 1990 as EC, transferred 2018 to EC]