EC - Apolipoprotein N-acyltransferase

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IntEnz Enzyme Nomenclature


Accepted name:
apolipoprotein N-acyltransferase
Other names:
lnt (gene name)
Systematic name:
phosphoglyceride:[apolipoprotein]-S-1,2-diacyl-sn-glyceryl-L-cysteine N-acyltransferase



This bacterial enzyme transfers a fatty acid from a membrane phospholipid to form an amide linkage with the N-terminal cysteine residue of apolipoproteins, generating a triacylated molecule.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
UniProtKB/Swiss-Prot: (92) [show] [UniProt]


  1. Gupta, S. D., Wu, H. C.
    Identification and subcellular localization of apolipoprotein N-acyltransferase in Escherichia coli.
    FEMS Microbiol. Lett. 62: 37-41 (1991). [PMID: 2032623]
  2. Robichon, C., Vidal-Ingigliardi, D., Pugsley, A. P.
    Depletion of apolipoprotein N-acyltransferase causes mislocalization of outer membrane lipoproteins in Escherichia coli.
    J. Biol. Chem. 280: 974-983 (2005). [PMID: 15513925]
  3. Hillmann, F., Argentini, M., Buddelmeijer, N.
    Kinetics and phospholipid specificity of apolipoprotein N-acyltransferase.
    J. Biol. Chem. 286: 27936-27946 (2011). [PMID: 21676878]

[EC created 2018]