EC 2.1.1.16 - Methylene-fatty-acyl-phospholipid synthase

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IntEnz Enzyme Nomenclature
EC 2.1.1.16

Names

Accepted name:
methylene-fatty-acyl-phospholipid synthase
Other name:
unsaturated-phospholipid methyltransferase
Systematic name:
S-adenosyl-L-methionine:unsaturated-phospholipid methyltransferase (methenylating)

Reaction

Comments:

The enzyme transfers a methyl group to the 10-position of a Δ-olefinic acyl chain in phosphatidylglycerol or phosphatidylinositol or, more slowly, phosphatidylethanolamine; subsequent proton transfer produces a 10-methylene group (cf. EC 2.1.1.79 cyclopropane-fatty-acyl-phospholipid synthase).

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0004481
CAS Registry Number: 37256-90-9

References

  1. Akamatsu, Y. and Law, J.H.
    Enzymatic alkylenation of phospholipid fatty acid chains by extracts of Mycobacterium phlei.
    J. Biol. Chem. 245: 701-708 (1970). [PMID: 4313604]

[EC 2.1.1.16 created 1972, modified 1986]