EC 1.14.14.85 - 7-deoxyloganate 7-hydroxylase

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IntEnz Enzyme Nomenclature
EC 1.14.14.85

Names

Accepted name:
7-deoxyloganate 7-hydroxylase
Other names:
CYP72A224
7-deoxyloganin 7-hydroxylase [incorrect]
7-deoxyloganin,[reduced NADPH—hemoprotein reductase]:oxygen oxidoreductase (7α-hydroxylating) (incorrect)
Systematic name:
7-deoxyloganate,[reduced NADPH—hemoprotein reductase]:oxygen oxidoreductase (7α-hydroxylating)

Reactions

Cofactor

Comments:

The enzyme, characterized from the plant Catharanthus roseus, is a cytochrome P450 (heme-thiolate) enzyme. It catalyses a reaction in the pathway leading to biosynthesis of monoterpenoid indole alkaloids. Formerly EC 1.14.13.74.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ERGO , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Protein domains and families: PROSITE:PDOC00081
Structural data: CSA , EC2PDB
CAS Registry Number: 335305-40-3

References

  1. Katano, N., Yamamoto, H., Iio, R. and Inoue, K.
    7-Deoxyloganin 7-hydroxylase in Lonicera japonica cell cultures.
    Phytochemistry 58: 53-58 (2001). [PMID: 11524113]
  2. Miettinen, K., Dong, L., Navrot, N., Schneider, T., Burlat, V., Pollier, J., Woittiez, L., van der Krol, S., Lugan, R., Ilc, T., Verpoorte, R., Oksman-Caldentey, K. M., Martinoia, E., Bouwmeester, H., Goossens, A., Memelink, J., Werck-Reichhart, D.
    The seco-iridoid pathway from Catharanthus roseus.
    Nat Commun 5: 3606 (2014). [PMID: 24710322]

[EC 1.14.14.85 created 2002 as EC 1.14.13.74, transferred 2018 to EC 1.14.14.85, modified 2018]