EC - Sulfide-dependent adenosine diphosphate thiazole synthase

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IntEnz Enzyme Nomenclature


Accepted name:
sulfide-dependent adenosine diphosphate thiazole synthase
Other name:
Thi4 [ambiguous]
Systematic name:
NAD+:glycine ADP-D-ribosyltransferase (sulfide-adding)



This iron dependent enzyme, found in most archaea, is involved in the biosynthesis of thiamine phosphate. The homologous enzyme from plants and fungi (EC, cysteine-dependent adenosine diphosphate thiazole synthase) uses an intrinsic cysteine as sulfur donor and, unlike the archaeal enzyme, is a single turn-over enzyme.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
UniProtKB/Swiss-Prot: (45) [show] [UniProt]


  1. Zhang, X., Eser, B. E., Chanani, P. K., Begley, T. P., Ealick, S. E.
    Structural Basis for Iron-Mediated Sulfur Transfer in Archael and Yeast Thiazole Synthases.
    Biochemistry 55: 1826-1838 (2016). [PMID: 26919468]
  2. Eser, B. E., Zhang, X., Chanani, P. K., Begley, T. P., Ealick, S. E.
    From Suicide Enzyme to Catalyst: The Iron-Dependent Sulfide Transfer in Methanococcus jannaschii Thiamin Thiazole Biosynthesis.
    J. Am. Chem. Soc. 138: 3639-3642 (2016). [PMID: 26928142]

[EC created 2018]