EC 1.14.19.55 - 4-hydroxybenzoate brominase (decarboxylating)

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ENZYME: 1.14.19.55


ID   1.14.19.55
DE   4-hydroxybenzoate brominase (decarboxylating).
CA   (1) 4-hydroxybenzoate + 2 NADPH + 2 bromide + 2 O(2) + 2 H(+) = 2,4-
CA   dibromophenol + 2 NADP(+) + CO(2) + 4 H(2)O.
CA   (2) 3,4-dihydroxybenzoate + 2 NADPH + 2 bromide + 2 O(2) + 2 H(+) = 3,5-
CA   dibromobenzene-1,2-diol + 2 NADP(+) + CO(2) + 4 H(2)O.
CF   FAD.
CC   -!- The enzyme, described from epiphytic marine bacteria of the genera
CC       Pseudoalteromonas and Marinomonas, is an unusual single-component
CC       FAD-dependent halogenase that contains a distinct NAD(P)H binding
CC       domain and does not require an additional flavin reductase for
CC       activity.
CC   -!- The enzyme catalyzes a bromination of its substrate, followed by a
CC       second bromination concurrent with decarboxylation.
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