EC 1.8.2.6 - S-disulfanyl-L-cysteine oxidoreductase

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IntEnz Enzyme Nomenclature
EC 1.8.2.6

Names

Accepted name:
S-disulfanyl-L-cysteine oxidoreductase
Other names:
SoxCD
sulfur dehydrogenase
Systematic name:
[SoxY protein]-S-disulfanyl-L-cysteine:cytochrome-c oxidoreductase

Reaction

Comments:

The enzyme is part of the Sox enzyme system, which participates in a bacterial thiosulfate oxidation pathway that produces sulfate. The enzyme from the bacterium Paracoccus pantotrophus contains a molybdoprotein component and a diheme c-type cytochrome component. The enzyme successively oxidizes the outer sulfur atom in [SoxY protein]-S-disulfanyl-L-cysteine, using three water molecules and forming [SoxY protein]-S-sulfosulfanyl-L-cysteine. During the process, six electrons are transferred to the electron chain via cytochrome c.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB

References

  1. Friedrich, C. G., Rother, D., Bardischewsky, F., Quentmeier, A., Fischer, J.
    Oxidation of reduced inorganic sulfur compounds by bacteria: emergence of a common mechanism?
    Appl. Environ. Microbiol. 67: 2873-2882 (2001). [PMID: 11425697]
  2. Bardischewsky, F., Quentmeier, A., Rother, D., Hellwig, P., Kostka, S., Friedrich, C. G.
    Sulfur dehydrogenase of Paracoccus pantotrophus: the heme-2 domain of the molybdoprotein cytochrome c complex is dispensable for catalytic activity.
    Biochemistry 44: 7024-7034 (2005). [PMID: 15865447]
  3. Grabarczyk, D. B., Berks, B. C.
    Intermediates in the Sox sulfur oxidation pathway are bound to a sulfane conjugate of the carrier protein SoxYZ.
    PLoS ONE 12: e0173395 (2017). [PMID: 28257465]

[EC 1.8.2.6 created 2018]