EC 4.3.2.8 - γ-glutamylamine cyclotransferase

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ENZYME: 4.3.2.8


ID   4.3.2.8
DE   Gamma-glutamylamine cyclotransferase.
CA   Epsilon-(gamma-L-glutamyl)-L-lysine = L-lysine + 5-oxo-L-proline.
CC   -!- The enzyme, found in vertebrates, has no activity toward alpha-
CC       (gamma-L-glutamyl)-L-amino acids (cf. EC 4.3.2.9).
CC   -!- The enzyme acts as a cyclotransferase, cleaving the amide bond via
CC       transamidation using the alpha-amine of the gamma-L-glutamyl residue,
CC       releasing it as the cyclic 5-oxo-L-proline.
DR   A0JMM9    , GGACA_DANRE;  Q66I06    , GGACB_DANRE;  A3KNL6    , GGACC_DANRE;
DR   Q923B0-2  , GGACT-2_MOUSE;  Q0VFX9    , GGACT_BOVIN;  Q9BVM4    , GGACT_HUMAN;
DR   Q923B0    , GGACT_MOUSE;  Q4KM86    , GGACT_RAT  ;  Q66KX0    , GGACT_XENLA;
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