EC 126.96.36.199 - γ-glutamylamine cyclotransferase
IntEnz Enzyme Nomenclature
- epsilon-(gamma-L-glutamyl)-L-lysine = L-lysine + 5-oxo-L-proline
The enzyme, found in vertebrates, has no activity toward α-(γ-L-glutamyl)-L-amino acids (cf. EC 188.8.131.52, γ-glutamylcyclotransferase). The enzyme acts as a cyclotransferase, cleaving the amide bond via transamidation using the α-amine of the γ-L-glutamyl residue, releasing it as the cyclic 5-oxo-L-proline.
Links to other databases
gamma-Glutamylamine cyclotransferase: specificity toward epsilon-(L-gamma-glutamyl)-L-lysine and related compounds.Proc. Natl. Acad. Sci. U.S.A. 77 : 4564-4568 (1980). [PMID: 6107907]
Identification and characterization of gamma-glutamylamine cyclotransferase, an enzyme responsible for gamma-glutamyl-epsilon-lysine catabolism.J. Biol. Chem. 285 : 9642-9648 (2010). [PMID: 20110353]
[EC 184.108.40.206 created 2017]