EC 4.2.3.166 - (+)-(1(10)E,4E,6S,7R)-germacradien-6-ol synthase

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IntEnz Enzyme Nomenclature
EC 4.2.3.166

Names

Accepted name:
(+)-(1(10)E,4E,6S,7R)-germacradien-6-ol synthase
Systematic name:
(2E,6E)-farnesyl-diphosphate diphosphate-lyase [cyclizing, (+)-(1(10)E,4E,6S,7R)-germacradien-6-ol-forming]

Reaction

Comments:

The enzyme has been identified in the bacterium Streptomyces pratensis. It is specific for (2E,6E)-farnesyl diphosphate.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
UniProtKB/Swiss-Prot:

References

  1. Rabe, P., Barra, L., Rinkel, J., Riclea, R., Citron, C. A., Klapschinski, T. A., Janusko, A., Dickschat, J. S.
    Conformational Analysis, Thermal Rearrangement, and EI-MS Fragmentation Mechanism of (1(10)E,4E,6S,7R)-Germacradien-6-ol by (13)C-Labeling Experiments.
    Angew. Chem. Int. Ed. Engl. 54: 13448-13451 (2015). [PMID: 26361082]

[EC 4.2.3.166 created 2017]