EC - RNA 2',3'-cyclic 3'-phosphodiesterase

  IntEnz view ENZYME view

IntEnz Enzyme Nomenclature


Accepted name:
RNA 2',3'-cyclic 3'-phosphodiesterase
Other names:
thpR (gene name)
ligT (gene name)
Systematic name:
(ribonucleotide)n-2',3'-cyclic phosphate 3'-nucleotidohydrolase



The enzyme hydrolyses RNA 2',3'-cyclic phosphodiester to an RNA 2'-phosphomonoester. In vitro the enzyme can also ligate tRNA molecules with 2',3'-cyclic phosphate to tRNA with 5'-hydroxyl termini, forming a 2'-5' phosphodiester linkage. However, the ligase activity is unlikely to be relevant in vivo.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
UniProtKB/Swiss-Prot: (12) [show] [UniProt]


  1. Kanai, A., Sato, A., Fukuda, Y., Okada, K., Matsuda, T., Sakamoto, T., Muto, Y., Yokoyama, S., Kawai, G., Tomita, M.
    Characterization of a heat-stable enzyme possessing GTP-dependent RNA ligase activity from a hyperthermophilic archaeon, Pyrococcus furiosus.
    RNA 15: 420-431 (2009). [PMID: 19155324]
  2. Remus, B. S., Jacewicz, A., Shuman, S.
    Structure and mechanism of E. coli RNA 2',3'-cyclic phosphodiesterase.
    RNA 20: 1697-1705 (2014). [PMID: 25239919]

[EC created 2017]