EC 1.14.14.54 - Phenylacetate 2-hydroxylase

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IntEnz Enzyme Nomenclature
EC 1.14.14.54

Names

Accepted name:
phenylacetate 2-hydroxylase
Other names:
CYP504
phaA (gene name)
Systematic name:
phenylacetate,[reduced NADPH—hemoprotein reductase]:oxygen oxidoreductase (2-hydroxylating)

Reaction

Cofactor

Comments:

This cytochrome P450 (heme-thiolate) enzyme, found in Aspergillus nidulans, is involved in the degradation of phenylacetate.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
UniProtKB/Swiss-Prot:

References

  1. Mingot, J. M., Penalva, M. A., Fernandez-Canon, J. M.
    Disruption of phacA, an Aspergillus nidulans gene encoding a novel cytochrome P450 monooxygenase catalyzing phenylacetate 2-hydroxylation, results in penicillin overproduction.
    J. Biol. Chem. 274: 14545-14550 (1999). [PMID: 10329644]
  2. Rodriguez-Saiz, M., Barredo, J. L., Moreno, M. A., Fernandez-Canon, J. M., Penalva, M. A., Diez, B.
    Reduced function of a phenylacetate-oxidizing cytochrome p450 caused strong genetic improvement in early phylogeny of penicillin-producing strains.
    J. Bacteriol. 183: 5465-5471 (2001). [PMID: 11544206]

[EC 1.14.14.54 created 2017]