EC - Ni-sirohydrochlorin a,c-diamide reductive cyclase

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IntEnz Enzyme Nomenclature


Accepted name:
Ni-sirohydrochlorin a,c-diamide reductive cyclase
Other names:
cfbC (gene name)
cfbD (gene name)
Systematic name:
Ni-sirohydrochlorin a,c-diamide reductive cyclo-ligase (ADP-forming)



The enzyme, studied from the methanogenic archaeon Methanosarcina acetivorans, participates in the biosynthesis of the nickel-containing tetrapyrrole cofactor coenzyme F430, which is required by EC, coenzyme-B sulfoethylthiotransferase.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB


  1. Pfaltz, A., Kobelt, A., Huster, R., Thauer, R. K.
    Biosynthesis of coenzyme F430 in methanogenic bacteria. Identification of 15,17(3)-seco-F430-17(3)-acid as an intermediate.
    Eur. J. Biochem. 170: 459-467 (1987). [PMID: 3691535]
  2. Zheng, K., Ngo, P. D., Owens, V. L., Yang, X. P., Mansoorabadi, S. O.
    The biosynthetic pathway of coenzyme F430 in methanogenic and methanotrophic archaea.
    Science 354: 339-342 (2016). [PMID: 27846569]

[EC created 2017]