EC 2.1.1.340 - 3-aminomethylindole N-methyltransferase

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IntEnz Enzyme Nomenclature
EC 2.1.1.340

Names

Accepted name:
3-aminomethylindole N-methyltransferase
Other name:
NMT (gene name)
Systematic name:
S-adenosyl-L-methionine:3-(aminomethyl)indole N-methyltransferase (gramine-forming)

Reaction

Comments:

The enzyme, characterized from Hordeum vulgare (barley), catalyses two successive N-methylation reactions during the biosynthesis of gramine, a toxic indole alkaloid.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
UniProtKB/Swiss-Prot:

References

  1. Leland, T. J., Hanson, A. D.
    Induction of a Specific N-Methyltransferase Enzyme by Long-Term Heat Stress during Barley Leaf Growth.
    Plant Physiol. 79 : 451-457 (1985). [PMID: 16664431]
  2. Larsson, K. A., Zetterlund, I., Delp, G., Jonsson, L. M.
    N-Methyltransferase involved in gramine biosynthesis in barley: cloning and characterization.
    Phytochemistry 67 : 2002-2008 (2006). [PMID: 16930646]

[EC 2.1.1.340 created 2017]