EC 1.14.11.55 - Ectoine hydroxylase

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IntEnz Enzyme Nomenclature
EC 1.14.11.55

Names

Accepted name:
ectoine hydroxylase
Other names:
ectD (gene name)
ectoine dioxygenase
Systematic name:
ectoine,2-oxoglutarate:oxygen oxidoreductase (5-hydroxylating)

Reaction

Cofactors

Comments:

Requires Fe2+ and ascorbate. The enzyme, found in bacteria, is specific for ectoine.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
UniProtKB/Swiss-Prot: (10) [show] [UniProt]

References

  1. Bursy, J., Pierik, A. J., Pica, N., Bremer, E.
    Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
    J. Biol. Chem. 282: 31147-31155 (2007). [PMID: 17636255]
  2. Bursy, J., Kuhlmann, A. U., Pittelkow, M., Hartmann, H., Jebbar, M., Pierik, A. J., Bremer, E.
    Synthesis and uptake of the compatible solutes ectoine and 5-hydroxyectoine by Streptomyces coelicolor A3(2) in response to salt and heat stresses.
    Appl. Environ. Microbiol. 74: 7286-7296 (2008). [PMID: 18849444]
  3. Reuter, K., Pittelkow, M., Bursy, J., Heine, A., Craan, T., Bremer, E.
    Synthesis of 5-hydroxyectoine from ectoine: crystal structure of the non-heme iron(II) and 2-oxoglutarate-dependent dioxygenase EctD.
    PLoS ONE 5: e10647 (2010). [PMID: 20498719]

[EC 1.14.11.55 created 2017]