EC - Ectoine hydroxylase

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IntEnz Enzyme Nomenclature


Accepted name:
ectoine hydroxylase
Other names:
ectD (gene name)
ectoine dioxygenase
Systematic name:
ectoine,2-oxoglutarate:oxygen oxidoreductase (5-hydroxylating)




Requires Fe2+ and ascorbate. The enzyme, found in bacteria, is specific for ectoine.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
UniProtKB/Swiss-Prot: (10) [show] [UniProt]


  1. Bursy, J., Pierik, A. J., Pica, N., Bremer, E.
    Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
    J. Biol. Chem. 282: 31147-31155 (2007). [PMID: 17636255]
  2. Bursy, J., Kuhlmann, A. U., Pittelkow, M., Hartmann, H., Jebbar, M., Pierik, A. J., Bremer, E.
    Synthesis and uptake of the compatible solutes ectoine and 5-hydroxyectoine by Streptomyces coelicolor A3(2) in response to salt and heat stresses.
    Appl. Environ. Microbiol. 74: 7286-7296 (2008). [PMID: 18849444]
  3. Reuter, K., Pittelkow, M., Bursy, J., Heine, A., Craan, T., Bremer, E.
    Synthesis of 5-hydroxyectoine from ectoine: crystal structure of the non-heme iron(II) and 2-oxoglutarate-dependent dioxygenase EctD.
    PLoS ONE 5: e10647 (2010). [PMID: 20498719]

[EC created 2017]