EC - N-terminal methionine Nα-acetyltransferase NatC

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IntEnz Enzyme Nomenclature


Accepted name:
N-terminal methionine Nα-acetyltransferase NatC
Other names:
NAA30 (gene name)
NAA35 (gene name)
NAA38 (gene name)
MAK3 (gene name)
MAK10 (gene name)
MAK31 (gene name)
Systematic name:
acetyl-CoA:N-terminal-Met-Leu/Ile/Phe/Trp/Tyr-[protein] Met Nα-acetyltransferase



N-terminal-acetylases (NATs) catalyse the covalent attachment of an acetyl moiety from acetyl-CoA to the free α-amino group at the N-terminus of a protein. This irreversible modification neutralizes the positive charge at the N-terminus and makes the N-terminal residue larger and more hydrophobic, and may also play a role in membrane targeting and gene silencing. The NatC complex is found in all eukaryotic organisms, and specifically targets N-terminal L-methionine residues attached to bulky hydrophobic residues at the second position, including Leu, Ile, Phe, Trp, and Tyr residues. Formerly EC

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB


  1. Polevoda, B., Sherman, F.
    NatC Nalpha-terminal acetyltransferase of yeast contains three subunits, Mak3p, Mak10p, and Mak31p.
    J. Biol. Chem. 276: 20154-20159 (2001). [PMID: 11274203]
  2. Polevoda, B., Sherman, F.
    Composition and function of the eukaryotic N-terminal acetyltransferase subunits.
    Biochem. Biophys. Res. Commun. 308: 1-11 (2003). [PMID: 12890471]
  3. Pesaresi, P., Gardner, N. A., Masiero, S., Dietzmann, A., Eichacker, L., Wickner, R., Salamini, F., Leister, D.
    Cytoplasmic N-terminal protein acetylation is required for efficient photosynthesis in Arabidopsis.
    Plant Cell 15: 1817-1832 (2003). [PMID: 12897255]
  4. Wenzlau, J. M., Garl, P. J., Simpson, P., Stenmark, K. R., West, J., Artinger, K. B., Nemenoff, R. A., Weiser-Evans, M. C.
    Embryonic growth-associated protein is one subunit of a novel N-terminal acetyltransferase complex essential for embryonic vascular development.
    Circ. Res. 98: 846-855 (2006). [PMID: 16484612]
  5. Starheim, K. K., Gromyko, D., Evjenth, R., Ryningen, A., Varhaug, J. E., Lillehaug, J. R., Arnesen, T.
    Knockdown of human N alpha-terminal acetyltransferase complex C leads to p53-dependent apoptosis and aberrant human Arl8b localization.
    Mol. Cell. Biol. 29: 3569-3581 (2009). [PMID: 19398576]

[created 1989 as EC, part-transferred 2016 to EC]