EC 1.17.8.1 - Hydroxysqualene dehydroxylase

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IntEnz Enzyme Nomenclature
EC 1.17.8.1

Names

Accepted name:
hydroxysqualene dehydroxylase
Other name:
hpnE (gene name)
Systematic name:
squalene:FAD oxidoreductase (hydroxylating)

Reaction

Comments:

This enzyme, isolated from the bacteria Rhodopseudomonas palustris and Zymomonas mobilis, participates, along with EC 2.5.1.103, presqualene diphosphate synthase, and EC 4.2.3.156, hydroxysqualene synthase, in the conversion of all-trans-farnesyl diphosphate to squalene. Eukaryotes achieve the same goal in a single step, catalysed by EC 2.5.1.21, squalene synthase.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
UniProtKB/Swiss-Prot:

References

  1. Pan, J. J., Solbiati, J. O., Ramamoorthy, G., Hillerich, B. S., Seidel, R. D., Cronan, J. E., Almo, S. C., Poulter, C. D.
    Biosynthesis of Squalene from Farnesyl Diphosphate in Bacteria: Three Steps Catalyzed by Three Enzymes.
    ACS Cent Sci 1: 77-82 (2015). [PMID: 26258173]

[EC 1.17.8.1 created 2016]