EC 1.1.1.397 - β-methylindole-3-pyruvate reductase

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IntEnz Enzyme Nomenclature
EC 1.1.1.397

Names

Accepted name:
β-methylindole-3-pyruvate reductase
Other name:
ind2 (gene name)
Systematic name:
(2S,3R)-2-hydroxy-3-(indol-3-yl)butanoate:NAD+ oxidoreductase

Reaction

Comments:

The enzyme, characterized from the bacterium Streptomyces griseus, participates in the biosynthesis of indolmycin, an antibacterial drug that inhibits the bacterial tryptophan--tRNA ligase (EC 6.1.1.2).

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
UniProtKB/Swiss-Prot:

References

  1. Du, Y. L., Alkhalaf, L. M., Ryan, K. S.
    In vitro reconstitution of indolmycin biosynthesis reveals the molecular basis of oxazolinone assembly.
    Proc. Natl. Acad. Sci. U.S.A. 112 : 2717-2722 (2015). [PMID: 25730866]

[EC 1.1.1.397 created 2016]