EC 1.14.14.24 - Vitamin D 25-hydroxylase

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ENZYME: 1.14.14.24


ID   1.14.14.24
DE   Vitamin D 25-hydroxylase.
AN   CYP2R1.
AN   Vitamin D(2) 25-hydroxylase.
AN   Vitamin D(3) 25-hydroxylase.
CA   Calciol + O(2) + [reduced NADPH--hemoprotein reductase] = calcidiol +
CA   [oxidized NADPH--hemoprotein reductase] + H(2)O.
CC   -!- A microsomal enzyme isolated from human and mouse liver that
CC       bioactivates vitamin D(3).
CC   -!- While multiple isoforms (CYP27A1, CYP2J2/3, CYP3A4, CYP2D25 and
CC       CYP2C11) are able to catalyze the reaction in vitro, only CYP2R1 is
CC       thought to catalyze the reaction in humans in vivo.
CC   -!- The direct electron donor to the enzyme is EC 1.6.2.4.
CC   -!- Formerly EC 1.14.13.159.
DR   Q6VVX0    , CP2R1_HUMAN;  Q6VVW9    , CP2R1_MOUSE;
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