EC 6.3.2.48 - L-arginine-specific L-amino acid ligase

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IntEnz Enzyme Nomenclature
EC 6.3.2.48

Names

Accepted name:
L-arginine-specific L-amino acid ligase
Other names:
RizA
L-amino acid ligase RizA
Systematic name:
L-arginine:L-amino acid ligase (ADP-forming)

Reaction

Cofactor

Comments:

The enzyme, characterized from the bacterium Bacillus subtilis, requires Mn2+ for activity. It shows strict substrate specificity toward L-arginine as the first (N-terminal) amino acid of the product. The second amino acid could be any standard protein-building amino acid except for L-proline.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
UniProtKB/Swiss-Prot:

References

  1. Kino, K., Kotanaka, Y., Arai, T., Yagasaki, M.
    A novel L-amino acid ligase from Bacillus subtilis NBRC3134, a microorganism producing peptide-antibiotic rhizocticin.
    Biosci. Biotechnol. Biochem. 73: 901-907 (2009). [PMID: 19352016]

[EC 6.3.2.48 created 2015]