EC - N-terminal E2 ubiquitin-conjugating enzyme

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IntEnz Enzyme Nomenclature


Accepted name:
N-terminal E2 ubiquitin-conjugating enzyme
Other names:
N-terminal ubiquitin-conjugating enzyme E2
Systematic name:
S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine:acceptor protein ubiquitin ligase (peptide bond-forming)



The enzyme ubiquitinylates the N-terminus of the acceptor protein. It is not reactive towards free lysine.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
UniProtKB/Swiss-Prot: (11) [show] [UniProt]


  1. Breitschopf, K., Bengal, E., Ziv, T., Admon, A., Ciechanover, A.
    A novel site for ubiquitination: the N-terminal residue, and not internal lysines of MyoD, is essential for conjugation and degradation of the protein.
    EMBO J. 17 : 5964-5973 (1998). [PMID: 9774340]
  2. Tatham, M. H., Plechanovova, A., Jaffray, E. G., Salmen, H., Hay, R. T.
    Ube2W conjugates ubiquitin to ?-amino groups of protein N-termini.
    Biochem. J. 453 : 137-145 (2013). [PMID: 23560854]
  3. Scaglione, K. M., Basrur, V., Ashraf, N. S., Konen, J. R., Elenitoba-Johnson, K. S., Todi, S. V., Paulson, H. L.
    The ubiquitin-conjugating enzyme (E2) Ube2w ubiquitinates the N terminus of substrates.
    J. Biol. Chem. 288 : 18784-18788 (2013). [PMID: 23696636]

[EC created 2015]